Spirovac is for vaccination of healthy cattle 4 weeks of age or older, including those pregnant and/or lactating, for the prevention of infection by Leptospira borgpetersenii serovar hardjo, including reproductive and renal tract colonization, and urinary shedding for up to 12 months. Vaccination with Spirovac also aids in the prevention of fetal infection. Spirovac contains inactivated whole cultures of L. borgpetersenii serovar hardjo-bovis

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PRODUCT CODE AND NAME: Spirovac; 91730, 91731

DESCRIPTION: Spirovac is the first vaccine for preventiom of infection by Leptospira borgpetersenii serovar hardjo, including reproductive and renal tract colonization and urinary shedding for up to 12 months. Vaccination with Spirovac also aids in prevention of fetal infection. Spirovac contains chemically inactivated whole cultures of L. borgpetersenii serovar hardjo.

ADVANTAGES: Protects against L. borgpetersenii serovar hardjo, which is found on average in more than 55% of US dairy herds. Contains an antigen not contained in standard 5-way vaccines that still experience infertility, delayed breeding and early embryonic death are suspect for leptospirosis caused by L. borgpetersenii serovar hardjo. Prevents L. borgpetersenii bacteria from infecting the kidneys and reproductive tract, stopping or reducing transmission. Provides 12-month duration of immunity, resulting in less time and labor required for vaccination. Safe for use in calves as young as 4 weeks, before they are at risk or become carriers. Stimulates a vigorous cell-mediated immune response, increasing protection against L borgpetersenii serovar hardjo.

DOSAGE AND ADMINISTRATION: General Directions: Vaccination of healthy cattle is recommended. Shake well. Aseptically administer 2 Ml subcutaneously. In accordance with Beef Quality Assurance guidelines, this product should be administered subcutaneously in the neck.Primary Vaccination: Healthy cattle should receive 2 doses administered 4-6 weeks apart. When used as an aid in preventing fetal infection, administer the second dose at least 2 weeks prior to breeding.Revaccination: Annual revaccination with a single dose is recommended.

PRECAUTIONS:1.\tUse entire contents when first opened.2.\tSterilized syringes and needles should be used to administer this vaccine.3.\tDo not vaccinate within 21 days before slaughter.4.\tAs with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.5.\tThis product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised or the vaccine is not administered in accordance with label directions.

QUESTIONS OR COMMENTS: Technical inquiries should be directed to Pfizer Animal Health Product Support, 1-800-366-5288.